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4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline → 4-(dimethylamino)-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | — |
| 反応物 | 4-(Dimethylamino)benzoyl chloride | HCID 4400782 | — |
| 反応物 | Dichloromethane methanol | HCID 21226129 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 4-(dimethylamino)-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | HCID 45137441 | 54.2% |
反応手順
Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (70 mg, 0.314 mmol) and 4-dimethylaminobenzoyl chloride (58 mg, 0.314 mmol) in dry pyridine (5 ml) to give the title compound (63 mg, 54%) as a pale yellow solid after work-up and flash chromatography (20:1 DCM/MeOH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895313B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-fdf45a17294b4b1198982c7a02dba115 |
| 出典メモ | uspto-grants-2014_11 |