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4-Nitrobenzoyl chloride → N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]-4-nitrobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| 反応物 | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | — |
| 反応物 | Ethylacetate methanol | HCID 21584119 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]-4-nitrobenzamide | HCID 58342125 | 80% |
反応手順
Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (0.20 g, 0.897 mmol) and 4-nitrobenzoyl chloride (0.166 g, 0.897 mmol) in dry pyridine (13 ml) to give the title compound (0.266 g, 80%) as a pale yellow solid after work-up and flash chromatography (1:1 EtOAc/MeOH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895313B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-fe898276a65c49af8b03987741888c7b |
| 出典メモ | uspto-grants-2014_11 |