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4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline → 3,4-difluoro-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | — |
| 反応物 | 3,4-Difluorobenzoyl chloride | HCID 2724519 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3,4-difluoro-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | HCID 58341981 | 68.3% |
反応手順
Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (0.50 g, 2.24 mmol) and 3,4-difluorobenzoyl chloride (0.395 g, 2.24 mmol) in dry pyridine (20 ml) to give the title compound (0.556 g, 68%) as a colourless solid after work-up and recrystallisation from AcOH.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895313B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-c21d0de92fd043f18b71606ca72dbfaf |
| 出典メモ | uspto-grants-2014_11 |