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4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline → 3-fluoro-4-methoxy-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | — |
| 反応物 | 3-Fluoro-4-methoxybenzoyl chloride | HCID 2779255 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3-fluoro-4-methoxy-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | HCID 58342126 | 71% |
反応手順
Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (0.30 g, 1.34 mmol) and 3-fluoro-4-methoxybenzoyl chloride (0.25 g, 1.34 mmol) in dry pyridine (14 ml) to give the title compound (0.357 g, 71%) as small, colourless needles after work-up, flash chromatography (DCM/MeOH 18:1) and recrystallisation from 1,4-dioxane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895313B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-00602f1556f54b44b69ed2ed0b3779af |
| 出典メモ | uspto-grants-2014_11 |