Triethylamine → 3-Amino-2-oxo-1-phenylpyrrolidine-3-carboxylic acid (3-chloro-5-fluorobenzyl)amide

HRID 339605

反応式

CCN(CC)CC.C(S)(S)CC.[Cl:13][C:14]1[CH:15]=[C:16]([CH:36]=[C:37]([F:39])[CH:38]=1)[CH2:17][NH:18][C:19]([C:21]1([N:33]=[N+]=[N-])[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:22]1=[O:32])=[O:20]>CO>[Cl:13][C:14]1[CH:15]=[C:16]([CH:36]=[C:37]([F:39])[CH:38]=1)[CH2:17][NH:18][C:19]([C:21]1([NH2:33])[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:22]1=[O:32])=[O:20]

参加物

実験手順

Et3N (0.1 ml, 0.75 mmol) followed by propanedithiol (0.08 ml, 0.75 mmol) are added to a solution of 3-azido-2-oxo-1-phenylpyrrolidine-3-carboxylic acid (3-chloro-5-fluorobenzyl)amide (100 mg, 0.25 mmol) in 2 ml of methanol. The batch is stirred at RT for 12 hours. When the reaction is complete, all volatile constituents are removed in vacuo, and the residue is purified on silica gel.

後処理

customall volatile constituents are removed in vacuo
customthe residue is purified on silica gel

出典と根拠

ORDレコード: ord-6d31dbd699b44efcac635c3acb941423
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08895535B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート