関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitrogen | HCID 947 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,8-Dibromoquinoline | HCID 45925951 | — |
| 反応物 | Vinylborate | HCID 86654342 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 溶媒 | Tetrahydrofuran 2-propanol | HCID 22597222 | — |
| 溶媒 | Water ethylacetate | HCID 22728543 | — |
| 生成物 | 8-Bromo-2-vinylquinoline | HCID 67234780 | — |
反応手順
To 2,8-dibromoquinoline (1.836 g, 6.398 mmol) in THF/IPA (20 mL/10 mL) was added vinylborate (0.9428 g, 7.038 mmol) and triethylamine (0.7769 g, 7.678 mmol). The reaction mixture was purged with N2, and PdCl2(dppf) dichloromethane adduct (0.3685 g, 0.4479 mmol) was added. The reaction was stirred at 55° C. for 12 hours, then cooled to ambient temperature. The reaction mixture was diluted with EtOAc/H2O, and the organic layer was separated and concentrated to provide the crude product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08895550B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-038c80a14fc94d0f85367248780f1fd4 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
