Water → HCID 58358814、化合物

HRID 339729ノート

反応式

HRID 339729 の反応式
Cl.[Cl:2][C:3]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:23][CH2:24][N:25]1[C:33](=[O:34])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]1=[O:35].O>CN(C=O)C>[Cl:2][C:3]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:23][CH2:24][N:25]2[C:26](=[O:35])[C:27]3[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:33]2=[O:34])[CH2:12][CH2:11]1

参加物

6

反応物 4

HCID 962WaterHCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 11430Potassium CarbonateHCID 116303721-(2,3-Dichlorophenyl)piperazine hydrochloride

生成物 1

HCID 58358814HCID 58358814、化合物収率 81.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1-(2,3-Dichlorophenyl)piperazine hydrochloride (3.16 g, 11.8 mmol) and potassium carbonate (4.08 g, 29.5 mmol) were added to the solution of 2-(2-bromoethyl)isoindoline-1,3-dione (3 g, 11.8 mmol) in DMF (20 ml). The reaction mixture was stirred for overnight at room temperature. After reaction complete, water (40 ml) was added and then normal work-up was taken. The residue was purified with normal phase preparative column to afford title compound (3.87 g, 81% yield) as white solid.

後処理

  1. customAfter reaction complete
  2. customThe residue was purified with normal phase preparative column

出典と根拠

ORDレコード
ord-afbf9f4227bf4c2f89588f0c444cdc09
出典データセット
uspto-grants-2014_11
特許番号
US08895558B2

反応ノート

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