(-)-Glycidol → (S)-glycidyl methanesulfonate

反応式

[CH3:1][S:2]([O:5][CH2:6][C@@H:7]1[O:9][CH2:8]1)(=[O:4])=[O:3].C1O[C@H]1CO>>[CH3:1][S:2]([O:5][CH2:6][C@H:7]1[O:9][CH2:8]1)(=[O:4])=[O:3]

参加物

反応物 2

HCID 6973630(-)-Glycidol

HCID 12461091(R)-glycidyl methanesulfonate

生成物 1

HCID 12461090(S)-glycidyl methanesulfonate

実験手順

(S)-Glycidyl Methanesulfonate was synthesized in an analogous manner to Intermediate F, Step 1, substituting (R)-(+)-glycidol for (S)-(−)-glycidol. This was used in further transformations as a solution of (S)-glycidyl methanesulfonate in DMF, without further purification.

後処理

customThis was used in further transformations as a solution of (S)-glycidyl methanesulfonate in DMF, without further purification

出典と根拠

ORDレコード: ord-6e7750a4e56947da837f0576cfca4275
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08895549B2

反応ノート

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