2,6-Dichloro-4-(trifluoromethyl)pyridine → 2-Chloro-6-methoxy-4-(trifluoromethyl)pyridine
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4](Cl)[N:3]=1.[OH-:13].[Na+].[CH3:15]O>CO>[CH3:15][O:13][C:4]1[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=[C:2]([Cl:1])[N:3]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 2,6-dichloro-4-trifluoromethylpyridine (10 g, 46.3 mmol) in methanol (200 mL) was added 25% NaOH/MeOH (12.5 g, 13.2 mL, 231 mmol), which was then stirred at 50° C. for 2 h and then at room temperature overnight. The reaction mixture was extracted with pentane, and the extract was concentrated in vacuo to afford 2-methoxy-6-chloro-4-trifluoromethylpyridine (9.79 g), used without further purification.
後処理
- customat room temperature
- customovernight
- extractionThe reaction mixture was extracted with pentane
- concentrationthe extract was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-b5c7d2dfeb7549569c8b8a811368072d
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895568B2
反応ノート
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