2,6-Dichloro-4-(trifluoromethyl)pyridine → 2-Chloro-6-methoxy-4-(trifluoromethyl)pyridine

HRID 339807

反応式

HRID 339807 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4](Cl)[N:3]=1.[OH-:13].[Na+].[CH3:15]O>CO>[CH3:15][O:13][C:4]1[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=[C:2]([Cl:1])[N:3]=1

参加物

4

反応物 2

HCID 5209682,6-Dichloro-4-(trifluoromethyl)pyridineHCID 23721981Sodium hydroxide methanol

生成物 1

HCID 568323142-Chloro-6-methoxy-4-(trifluoromethyl)pyridine収率 99.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

To a solution of 2,6-dichloro-4-trifluoromethylpyridine (10 g, 46.3 mmol) in methanol (200 mL) was added 25% NaOH/MeOH (12.5 g, 13.2 mL, 231 mmol), which was then stirred at 50° C. for 2 h and then at room temperature overnight. The reaction mixture was extracted with pentane, and the extract was concentrated in vacuo to afford 2-methoxy-6-chloro-4-trifluoromethylpyridine (9.79 g), used without further purification.

後処理

  1. customat room temperature
  2. customovernight
  3. extractionThe reaction mixture was extracted with pentane
  4. concentrationthe extract was concentrated in vacuo

出典と根拠

ORDレコード
ord-b5c7d2dfeb7549569c8b8a811368072d
出典データセット
uspto-grants-2014_11
特許番号
US08895568B2

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