Malonic Acid → 3-Amino-3-(2,5-difluorophenyl)propanoic acid
反応式
[F:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH:4]=O.[C:11]([OH:17])(=[O:16])[CH2:12]C(O)=O.C([O-])(=O)C.[NH4+:22]>C(O)C>[NH2:22][CH:4]([C:3]1[CH:6]=[C:7]([F:10])[CH:8]=[CH:9][C:2]=1[F:1])[CH2:12][C:11]([OH:17])=[O:16]参加物
5
実験手順
A solution of 2,5-difluorobenzaldehyde (5 g), malonic acid (3.66 g) and ammonium acetate (5.42 g) in ethanol (50 ml) was heated under reflux for six hours. The mixture was cooled and left to stand overnight. The crystals formed were filtered off and washed with ethanol (5 ml).
後処理
- temperatureunder reflux for six hours
- temperatureThe mixture was cooled
- waitleft
- customThe crystals formed
- filtrationwere filtered off
- washwashed with ethanol (5 ml)
出典と根拠
- ORDレコード
- ord-6689b046683d40b2bf586448f5338a30
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895547B2
反応ノート
読み込み中…