Hydrochloric Acid → (2S)-2-amino-3-(2-methoxypyridin-4-yl)propan-1-ol
反応式
[OH:1][CH2:2][C@@H:3]([NH:13]C(=O)OC(C)(C)C)[CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([O:11][CH3:12])[CH:6]=1.CO.Cl>O1CCOCC1>[NH2:13][C@@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([O:11][CH3:12])[CH:6]=1)[CH2:2][OH:1]参加物
5
実験手順
To a vial was added tert-butyl {(1S)-2-hydroxy-1-[(2-methoxypyridin-4-yl)methyl]ethyl}carbamate (0.50 g, 1.8 mmol) and methanol (2.0 mL) and 4.0 M hydrogen chloride in dioxane (5.0 mL, 20. mmol). The reaction was stirred at room temperature overnight. Direct evaporation under reduced pressure afforded the final compound. LC-MS found: 183.0 (M+H)+.
後処理
- customDirect evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-bf2fac308f5e43a48dd05446ff79197b
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895571B2
反応ノート
読み込み中…