HCID 86681478、化合物 → Ethyl 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

反応式

[NH2:1]/[C:2](=[C:4](\[C:11]([O:13][CH2:14][CH3:15])=[O:12])/[CH:5]=[CH:6]/[C:7](OC)=[O:8])/[CH3:3]>CN(C=O)C>[CH3:3][C:2]1[NH:1][C:7](=[O:8])[CH:6]=[CH:5][C:4]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

参加物

反応条件

温度: 165 °C

実験手順

5-Ethyl 1-methyl (2E,4Z)-4-(1-aminoethylidene)pent-2-enedioate (10 g, 50 mmol) and DMF (30 mL) were mixed in one 100 mL flask, and the mixture was stirred at 165° C. for 14 hrs. The reaction mixture was cooled to room temperature, then filtered to give the crude product, which was washed with DMF and small amount of methanol to give 5 g (60% yield) of the pure product. LC-MS found: 182.1 (M+H)+.

後処理

temperatureThe reaction mixture was cooled to room temperature
filtrationfiltered
customto give the crude product, which
washwas washed with DMF and small amount of methanol

出典と根拠

ORDレコード: ord-1e263c928d774423aef171f46f38c3b2
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08895571B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 86681478HCID 86681478、化合物

生成物 1

HCID 3299500Ethyl 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate収率 60%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度: 165 °C

実験手順

後処理

temperatureThe reaction mixture was cooled to room temperature
filtrationfiltered
customto give the crude product, which
washwas washed with DMF and small amount of methanol

出典と根拠

ORDレコード: ord-1e263c928d774423aef171f46f38c3b2
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08895571B2

反応ノート

読み込み中…