tert-Butyl (2S)-2-methylpiperazine-1-carboxylate → HCID 178436931、化合物

HRID 340055ノート

反応式

HRID 340055 の反応式
Cl[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][C:13]3[NH:16][C:17]([C:19]4[C:27]5[C:22](=[CH:23][C:24]([C:28]6[CH:33]=[C:32]([F:34])[C:31]([OH:35])=[CH:30][C:29]=6[CH2:36][CH3:37])=[CH:25][CH:26]=5)[NH:21][N:20]=4)=[N:18][C:12]=3[CH2:11]2)=[O:9])=[N:6][CH:7]=1.C(OC([N:45]1[CH2:50][CH2:49][NH:48][CH2:47][C@@H:46]1[CH3:51])=O)(C)(C)C>>[CH2:36]([C:29]1[CH:30]=[C:31]([OH:35])[C:32]([F:34])=[CH:33][C:28]=1[C:24]1[CH:23]=[C:22]2[C:27]([C:19]([C:17]3[NH:16][C:13]4[CH2:14][CH2:15][N:10]([C:8]([C:5]5[N:6]=[CH:7][C:2]([N:48]6[CH2:49][CH2:50][NH:45][C@@H:46]([CH3:51])[CH2:47]6)=[N:3][CH:4]=5)=[O:9])[CH2:11][C:12]=4[N:18]=3)=[N:20][NH:21]2)=[CH:26][CH:25]=1)[CH3:37]

参加物

3

反応物 2

HCID 10081508tert-Butyl (2S)-2-methylpiperazine-1-carboxylateHCID 178436919HCID 178436919、化合物

生成物 1

HCID 178436931HCID 178436931、化合物収率 25.8%

実験手順

The title compound was prepared from (5-chloropyrazin-2-yl)(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (200 mg, 386 μmol) and (S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester (155 mg, 773 μmol) using the method from Example 61. After purification by HPLC Method E and deprotection using HCl/dioxan, the title compound (58 mg, 25% yield over two steps) was obtained as off-white solid (HCl-salt).

後処理

  1. customAfter purification by HPLC Method E and deprotection

出典と根拠

ORDレコード
ord-52f99fcbc8cf4cacbb8ee6b8b4f5c0ff
出典データセット
uspto-grants-2014_11
特許番号
US08895544B2

反応ノート

読み込み中…