Triethylamine → 1-benzyl-3-phenyl-1H-pyrazol-5-amine

HRID 34006

反応式

HRID 34006 の反応式
[C:1]([CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O)#[N:2].Cl.Cl.[CH2:14]([NH:21][NH2:22])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(CC)CC)C>C(O)C>[CH2:14]([N:21]1[C:1]([NH2:2])=[CH:3][C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[N:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 64799BenzoylacetonitrileHCID 146540Benzylhydrazine dihydrochloride

生成物 1

HCID 6847461-benzyl-3-phenyl-1H-pyrazol-5-amine収率 82.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.9 g of α-cyanoacetophenone and 3.9 g of benzyl hydrazine dihydrochloride were suspended in 50 mL of ethanol. The reaction solution was added with 6.0 ml of triethylamine at room temperature, and heated under reflux for 4 hours. The solvent was evaporated, and the residue was added with water, extracted with ethyl acetate, and dried over anhydrous sodium sulfate. After distilling off the solvent, the residue was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:4), to afford 4.1 g of the title compound as a yellow needle powder.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. customThe solvent was evaporated
  4. additionthe residue was added with water
  5. extractionextracted with ethyl acetate
  6. dry with materialdried over anhydrous sodium sulfate
  7. distillationAfter distilling off the solvent
  8. customthe residue was purified
  9. customseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:4)

出典と根拠

ORDレコード
ord-ab741d29a856446f992b176cf69abef4
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

関連ノート

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