(2-Chlorothiophen-3-yl)naphthalen-2-yl Methanol → (2-Chlorothiophen-3-yl)-(naphthalen-2-yl)-methanone
反応式
[Cl:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH:7]([C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1)[OH:8]>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1)=[O:8]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 1.18 g of (2-chlorothiophen-3-yl)-(naphthalen-2-yl)-methanol in 12 mL of toluene was added 1.12 g of activated manganese dioxide at room temperature, and after stirring at 50° C. for a day, manganese dioxide was filtered off through Celite. The solvent was distilled off, and the resultant crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:50), to afford 0.61 g of the title compound as a colorless oil.