Cesium fluoride → 5-Bromo-2,3-difluorobenzaldehyde
反応式
[Br:1][C:2]1[C:3]([Si](C)(C)C)=[C:4]([F:11])[C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[F-].[Cs+]>CN(C)C=O.O.C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8]参加物
6
実験手順
To a solution of 18.0 g of 5-bromo-2,3-difluoro-4-trimethylsilanyl benzaldehyde in 20 mL of N,N-dimethylformamide and 2 mL of water was added 1.63 g of cesium fluoride at room temperature, and stirred at this temperature for 1 hour. After diluting with ethyl acetate, the organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 10.26 g of the title compound as a colorless oil.
後処理
- washthe organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-fddcc1bba83a4ad4804828b8fcf6c8d4
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429609B2
反応ノート
読み込み中…