化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-((E)-2-(3-fluorophenyl)ethenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 3-Fluorostyrene | HCID 67691 | — |
| 反応物 | 4,4,5,5-Tetramethyl[1,3,2]dioxaborolane | HCID 2734768 | — |
| 触媒 | Rhodium, di-mu-chlorobis((1,2,5,6-eta)-1,5-cyclooctadiene)di- | HCID 6436379 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-((E)-2-(3-fluorophenyl)ethenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 59797036 | — |
反応手順
To a solution of 11 mg of chloro(1,5-cyclooctadiene)-rhodium(I) dimer and 0.61 mL of 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane in 15 mL toluene was added dropwise 1.0 mL of 3-fluorostyrene, and stirred at room temperature for 4 hours. The reaction solution was added with water, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the resultant crude product was purified and separated by silica gel column chromatography (diethyl ether:n-hexane=1:19), to afford 311 mg of the title compound as a pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429609B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-19f3cf7530ff411ea7fc46d3b23c22cf |
| 出典メモ | uspto-grants-2008_09 |