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Benzyltriphenylphosphonium bromide → 8-Phenethylbenzo[f][1,7]naphthyridin-5-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyltriphenylphosphonium bromide | HCID 2734970 | — |
| 反応物 | 5-Aminobenzo[f][1,7]naphthyridine-8-carbaldehyde | HCID 86652355 | — |
| 生成物 | 8-Phenethylbenzo[f][1,7]naphthyridin-5-amine | HCID 58213779 | — |
反応手順
8-Phenethylbenzo[f][1,7]naphthyridin-5-amine was prepared from 5-aminobenzo[f][1,7]naphthyridine-8-carbaldehyde (from Example 87) with benzyltriphenylphosphonium bromide following the procedures described for Example 91 (wittig reaction) and Example 92 (reduction). 1H NMR (acetone-d6): δ 8.99 (dd, 1H), 8.88 (dd, 1H), 8.35 (d, 1H), 7.83 (dd, 1H), 7.49 (d, 1H), 7.29-7.15 (dd, 6H), 6.70 (br s, 2H), 3.10-3.00 (m, 4H). LRMS [M+H]=300.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895577B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-34cec331caf449b1985d8e1a8a81128d |
| 出典メモ | uspto-grants-2014_11 |