Acetic Acid → HCID 59797236、化合物

HRID 34034ノート

反応式

HRID 34034 の反応式
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=3)=[N:7][N:8]2C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:4][C:3]=1[NH2:39].[C:40]([OH:43])(=O)[CH3:41]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=3)=[N:7][NH:8]2)=[CH:4][C:3]=1[NH:39][C:40](=[O:43])[CH3:41]

参加物

3

反応物 2

HCID 176Acetic AcidHCID 68932237HCID 68932237、化合物

生成物 1

HCID 59797236HCID 59797236、化合物

実験手順

525 mg of 6-fluoro-3-[(E)-2-(3-fluorophenyl)-vinyl]-1-trityl-1H-indazol-5-ylamine and 80 μl of glacial acetic acid were dehydraing-condensed in accordance with Example 127, followed by deprotection in the similar method as described in Example 16, to afford 150 mg of the title compound as bright yellow crystals.

後処理

  1. customdehydraing-condensed in accordance with Example 127

出典と根拠

ORDレコード
ord-63b07e23401b4d93b02ac0c3d93b842e
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

反応ノート

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