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Water → N-methoxy-N-propargyl-p-chlorobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Propargyl bromide | HCID 7842 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-chloro-N-methoxybenzamide | HCID 12610570 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-methoxy-N-propargyl-p-chlorobenzamide | HCID 18935031 | 36.5% |
反応手順
0.22 g of sodium hydride (60% in oil) was suspended in 10 ml of tetrahydrofuran, and 1.0 g of N-methoxy-p-chlorobenzamide and 0.68 g of propargyl bromide were added thereto in this order while being cooled with ice. The mixture was heat-refluxed for 8 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.44 g of N-methoxy-N-propargyl-p-chlorobenzamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733935 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-70e031461ff64ee8941f84d430c91d71 |
| 出典メモ | uspto-grants-1998_03 |