Water → HCID 59797368、化合物

HRID 34042ノート

反応式

HRID 34042 の反応式
[CH3:1][O:2][C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:6][NH:7]2.[OH2:22]>S(=O)(=O)(O)O>[CH3:1][O:2][C:3]1[C:11]([C:12]([NH2:13])=[O:22])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:6][NH:7]2

参加物

4

反応物 2

HCID 962WaterHCID 59797311HCID 59797311、化合物

生成物 1

HCID 59797368HCID 59797368、化合物

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
110 °C

実験手順

35 mg of 4-methoxy-3-(E)-styryl-1H-indazole-5-carbonitrile was dissolved in a mixed solvent 2 mL concentrated sulfuric acid/1 mL water, and stirred at 110° C. for 1 hour and 15 minutes. After cooling the reaction mixture on ice, water was slowly poured under ice cooling, and the precipitated crystals were collected by filtration, and washed with water. After drying under reduced pressure, 22 mg of the title compound was obtained as brown crude crystals.

後処理

  1. additionwas slowly poured under ice cooling
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customAfter drying under reduced pressure

出典と根拠

ORDレコード
ord-08e09919d2a84b068666e3fd16037872
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

反応ノート

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