Ethanol → CID 59797354

HRID 34044ノート

反応式

HRID 34044 の反応式
[CH3:1][O:2][C:3]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][NH:7]2.[CH2:15](O)[CH3:16]>O>[CH2:15]([O:13][C:12]([C:11]1[C:3]([O:2][CH3:1])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2)=[O:14])[CH3:16]

参加物

4

反応物 2

HCID 702EthanolHCID 23070119CID 23070119

生成物 1

HCID 59797354CID 59797354

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
95 °C

実験手順

2 g of 4-methoxy-1H-indazole-5-carboxylic acid was added to a mixed solvent of 40 mL ethanol/2.2 mL concentrated sulfuric acid, and stirred at 95° C. for 11 hours. After cooling the reaction solution on ice, water was slowly added under ice cooling, and the precipitated crystals were collected by filtration and washed with water. Thereafter, the crystals were dried under reduced pressure, to afford 1.52 g of the title compound as pale brown crude crystals.

後処理

  1. additionwas slowly added under ice cooling
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customThereafter, the crystals were dried under reduced pressure

出典と根拠

ORDレコード
ord-29bbec0e7d9247aab261bd096818d609
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

反応ノート

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