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Dimethylformamide → propargyl N-methoxy-2,4-dichlorobenzimidate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Propargyl bromide | HCID 7842 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,4-dichloro-N-methoxybenzamide | HCID 18935035 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | propargyl N-methoxy-2,4-dichlorobenzimidate | HCID 53654798 | 29.8% |
反応手順
1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733935 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-bc47ddbc82764811b755545cf676a4fc |
| 出典メモ | uspto-grants-1998_03 |