関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diiodomethane | HCID 6346 | — |
| 反応物 | 2-Amino-4-methyl-5-nitropyridine | HCID 243165 | — |
| 反応物 | Isopentyl sulfite | HCID 22742080 | — |
| 生成物 | 2-Iodo-4-methyl-5-nitropyridine | HCID 23070167 | — |
反応手順
To a solution of 1.0 g of 2-amino-4-methyl-5-nitropyridine in 10 mL of diiodomethane was added 1.8 mL of isopentyl sulfite at room temperature, stirred at this temperature for 30 minutes, and after raising the temperature to 80° C., the solution was stirred for 2 hours. The diiodomethane was evaporated, and the crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:20), to afford 897 mg of the title compound as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07429609B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-4591426222324116a52532a1d4076497 |
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| 出典メモ | uspto-grants-2008_09 |
|---|
