4-Bromo-7-hydroxy-6-nitro-2,3-dihydro-1H-inden-1-one → 6-Amino-7-hydroxy-2,3-dihydro-1H-inden-1-one hydrobromide
反応式
[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([OH:14])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:15]>CO.[C].[Pd]>[BrH:1].[NH2:11][C:9]1[C:8]([OH:14])=[C:7]2[C:3]([CH2:4][CH2:5][C:6]2=[O:15])=[CH:2][CH:10]=1参加物
4
実験手順
4-Bromo-7-hydroxy-6-nitroindan-1-one (2.90 g, 10.66 mmol) was dissolved in methanol (53 mL), a 10% palladium-carbon powder (290 mg) was added, and the mixture was stirred at room temperature for 6 hr under a hydrogen atmosphere. The catalyst was filtered off using celite, and the filtrate was concentrated under reduced pressure to give the title compound (2.08 g, yield 80%).
後処理
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-19e0ccbbe1434650ac0fafb48f1b169a
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895591B2
反応ノート
読み込み中…