Triacetoxyperiodinane → 5-Chloro-4-formylthiophene-2-carbonitrile

HRID 34073ノート

反応式

HRID 34073 の反応式
[Cl:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[CH:4][C:3]=1[CH2:9][OH:10].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[Cl:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[CH:4][C:3]=1[CH:9]=[O:10]

参加物

4

反応物 2

HCID 159087TriacetoxyperiodinaneHCID 230701655-Chloro-4-hydroxymethylthiophene-2-carbonitrile

生成物 1

HCID 230702115-Chloro-4-formylthiophene-2-carbonitrile収率 151.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 3.0 g of 5-chloro-4-hydroxymethylthiophene-2-carbonitrile in 34 mL of dichloromethane was added 8.06 g of Dess-Martin reagent at room temperature, and stirred at this temperature for a day. After diluting with dichloromethane, washing successively with aqueous sodium hydrogen carbonate and saturated brine, and drying over anhydrous magnesium sulfate, the solvent was evaporated, to afford 4.5 g of a crude product of the title compound as colorless crystals.

後処理

  1. washwashing successively with aqueous sodium hydrogen carbonate and saturated brine
  2. dry with materialdrying over anhydrous magnesium sulfate
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-fc6f0aba60704c4dabaaa80653a14acb
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

反応ノート

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