Hydrochloric Acid → 3-Azabicyclo[3.1.0]hexane-6-carboxamide HCl
反応式
Cl.[C:2]([CH:5]1[CH:10]2[CH:6]1[CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9]2)(=[O:4])[NH2:3].C(Cl)[Cl:19]>CO>[ClH:19].[CH:6]12[CH:5]([C:2]([NH2:3])=[O:4])[CH:10]1[CH2:9][NH:8][CH2:7]2参加物
5
実験手順
1.25 M hydrochloric acid solution (9.76 mL, 12.2 mmol) dissolved in methanol was added dropwise to the tert-butyl 6-carbamoyl-3-azabicyclo[3.1.0]hexane-3-carboxylate (177 mg, 0.784 mmol) prepared in Example 4 and stirred for 3 hours. The completion of the reaction was confirmed by TLC (CH2Cl2:MeOH=15:1). After the reaction was completed, the reaction mixture was concentrated under reduced pressure to obtain 127 mg (100%) of the target compound.
後処理
- concentrationthe reaction mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-c7de6d02bb08447bacde1988d8a7503f
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08895602B1
反応ノート
読み込み中…