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(2,6-Dichlorophenyl)acetonitrile → 6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2,6-Dichlorophenyl)acetonitrile | HCID 76678 | — |
| 反応物 | 2,4-Diaminopyrimidine-5-carbaldehyde | HCID 309176 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Sodium 2-ethoxyethoxide | HCID 23667900 | — |
| 溶媒 | Glycol monoethyl ether | HCID 8076 | — |
| 生成物 | 6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328113 | — |
反応手順
(Prepared by the method of U.S. Pat. No. 3,534,039). To a solution of sodium 2-ethoxyethoxide prepared from 0.14 g of sodium and 60 mL of 2-ethoxyethanol was added 2.07 g of 2,4-diamino-5-pyrimidinecarboxaldehyde and 2.79 g of 2,6-dichlorophenylacetonitrile. The mixture is heated at reflux for 4 hours, cooled, and the insoluble product washed with diethylether to give 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine, mp 325-332° C. (MS).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733913 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-45783ee212a64703af0373922cf64354 |
| 出典メモ | uspto-grants-1998_03 |