Hydrazine → 6-Fluoroisoquinoline-3-carbohydrazide

HRID 340882ノート

反応式

HRID 340882 の反応式
C[O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[CH:10][CH:9]=2)=O.[NH2:16][NH2:17]>C(O)C>[F:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH:7]=[N:6][C:5]([C:3]([NH:16][NH2:17])=[O:2])=[CH:14]2

参加物

4

反応物 2

HCID 9321HydrazineHCID 57947434Methyl 6-fluoroisoquinoline-3-carboxylate

生成物 1

HCID 579481706-Fluoroisoquinoline-3-carbohydrazide収率 84.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 6-fluoro-isoquinoline-3-carboxylic acid methyl ester (27 g) and hydrazine (42 g, 10 equiv.) in ethanol (500 mL) was refluxed for 2 h. The reaction mixture was concentrated under high vacuum to remove hydrazine, and the resulting residue was triturated with ethanol (100 mL) to give 6-fluoro-isoquinoline-3-carboxylic acid hydrazide as a light yellow solid (22.8 g, 84%). LRMS (M+H+) m/z 206.1.

後処理

  1. concentrationThe reaction mixture was concentrated under high vacuum
  2. customto remove hydrazine
  3. customthe resulting residue was triturated with ethanol (100 mL)

出典と根拠

ORDレコード
ord-383bdf35eb29407fb9d7b0d1a9506bd4
出典データセット
uspto-grants-2014_11
特許番号
US08895582B2

反応ノート

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