Water → ethyl 5-bromo-2H-indazole-3-carboxylate

HRID 34093ノート

反応式

HRID 34093 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.O.[C:20](OCC)(=O)[CH3:21]>C(O)C>[CH2:20]([O:12][C:11]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=2)[NH:7][N:6]=1)=[O:13])[CH3:21]

参加物

6

反応物 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 8857Ethyl AcetateHCID 71573585-bromo-1H-indazole-3-carboxylic Acid

生成物 1

HCID 12689364ethyl 5-bromo-2H-indazole-3-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3 g of 5-bromo-1H-indazole-3-carboxylic acid was dissolved in 60 mL of ethanol, added with 0.6 mL of concentrated sulfuric acid, and heated under reflux for 8 hours. After allowing to cool to room temperature, addition of water and extraction with ethyl acetate were conducted, and the resultant organic layer was washed with saturated aqueous sodium hydrogen carbonate and saturated brine, dried over magnesium sulfate, and the solvent was evaporated, to afford 2.7 g of the title compound as yellow crystals.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 8 hours
  3. washthe resultant organic layer was washed with saturated aqueous sodium hydrogen carbonate and saturated brine
  4. dry with materialdried over magnesium sulfate
  5. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-d77850c85fd540af9825519a7b12cb14
出典データセット
uspto-grants-2008_09
特許番号
US07429609B2

反応ノート

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