Hydrochloric Acid → HCID 178418440、化合物

HRID 3410ノート

反応式

HRID 3410 の反応式
Cl.S(OS([O-])(=O)=O)([O-])(=O)=[O:3].[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19](N)=[N:18][C:16]=2[N:17]=1>O>[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19]([OH:3])=[N:18][C:16]=2[N:17]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 177717DisulfateHCID 108474752,7-Diamino-6-phenylpyrido[2,3-d]pyrimidine

生成物 1

HCID 178418440HCID 178418440、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 2 L of concentrated HCl and 1 L of water is added 300 g of the disulfate salt of 2,7-diamino-6-phenylpyrido[2,3-d]pyrimidine and the resulting mixture refluxed with stirring overnight. The reaction mixture is cooled in an ice bath, filtered, and the insoluble product washed with water, followed by ethanol to give 149 g of the title compound 2-amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-ol, mp 390°-395° C. (darkens slowly above 350° C.).

後処理

  1. temperaturethe resulting mixture refluxed
  2. temperatureThe reaction mixture is cooled in an ice bath
  3. filtrationfiltered
  4. washthe insoluble product washed with water

出典と根拠

ORDレコード
ord-8ab3a8e6f55f47d8b365c3064b07de67
出典データセット
uspto-grants-1998_03
特許番号
US05733913

反応ノート

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