反応式
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=O.[C:8](=[O:15])([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[NH2:9].[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22]([O-])(=[O:24])=[O:23])=[CH:18][CH:17]=1.[Na+].C(O)=O>CO.O>[C:11]([O:10][C:8](=[O:15])[NH:9][CH:6]([C:2]1[O:1][CH:5]=[CH:4][N:3]=1)[S:22]([C:19]1[CH:20]=[CH:21][C:16]([CH3:26])=[CH:17][CH:18]=1)(=[O:24])=[O:23])([CH3:14])([CH3:13])[CH3:12]参加物
7
実験手順
300 mg of oxazole 2-carboaldehyde was dissolved in a mixed solvent of 3 mL of methanol and 6 mL of water, added successively with 363 mg of tert-butyl carbamate, 552 mg of sodium p-toluenesulfonate and 0.76 mL of formic acid and stirred at room temperature for 16 hours and 30 minutes. The precipitated crystals were collected by filtration, washed with water, and dried under reduced pressure, to afford 247 mg of the title compound as colorless crystals.
後処理
- filtrationThe precipitated crystals were collected by filtration
- washwashed with water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-3b7aa62a381549e18666f9b8cf1832d0
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429609B2
関連ノート
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