tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate → tert-Butyl (R)-3-phenoxypyrrolidine-1-carboxylate
反応式
O[C@H]1CCN(C(OC(C)(C)C)=O)C1.[O:14]([C@H:21]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[O:14]([C@@H:21]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1参加物
3
実験手順
tert-Butyl (3R)-3-phenoxypyrrolidine-1-carboxylate was prepared from tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate (0.43 g, 2.286 mmol) according to the method described for Intermediate 270 to afford the title compound (0.312 g, 51% yield). Method B HPLC-MS: MH+ requires m/z=208 Found: m/z=208, Rt=2.20 min (100%).
出典と根拠
- ORDレコード
- ord-ee7c04f87cd04381a9f4d7418bc9e29b
- 出典データセット
- uspto-grants-2014_11