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Ethyl isocyanate → 1-[2-Amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl isocyanate | HCID 8022 | — |
| 反応物 | 6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328113 | — |
| 生成物 | 1-[2-Amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea | HCID 10738332 | — |
反応手順
2,7-Diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine was reacted with ethyl isocyanate according to the general procedure of Example 2. The crude product was purified by radial chromatography eluting with a gradient of 70% ethyl acetate/30% chloroform to 100% chloroform to give the title compound, 1-[2-amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea, mp 185°-187° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733913 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-364ed88f220643f79ef9dda9075acba3 |
| 出典メモ | uspto-grants-1998_03 |