関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Trifluoromethanesulfonic anhydride | HCID 67749 | — |
| 反応物 | Lactate | HCID 91435 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(((Trifluoromethyl)sulfonyl)oxy)acetic acid methyl ester | HCID 11229773 | 90% |
反応手順
10.09 ml (60 mmol) trifluorometansulfonic anhydrid dissolved in CH2Cl2 was added dropwise to a mixture of 4.05 ml (50 mmol) methylglycolate and 4.04 ml (50 mmol) pyridin in CH2Cl2 (totally 62.5 ml) at 0° C. during 25 minutes, and thereafter stirred at 0° C. for 1 H. After washing with 0.3M KHSO4 and saturated NA2CO3, drying (Na2SO4) and filtration, evaporation of the solvent in vacuo gave 9.94 g (90%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05856307 |
|---|
| 出典データセット | uspto-grants-1999_01 |
|---|
| ORD ID | ord-ed848f084cb34979af6207996e646ec0 |
|---|
| 出典メモ | uspto-grants-1999_01 |
|---|
