5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol → 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol hydrochloride

HRID 341829ノート

反応式

HRID 341829 の反応式
[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([OH:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22].CO>CCOCC.ClCCl>[ClH:22].[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([OH:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 98604535,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-olHCID 21893726Hydrochloride methanol

生成物 1

HCID 675964275,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

A portion (0.2 g) of 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol obtained in Example 4 was dissolved in ether (10 mL) and dichloromethane (10 mL); following the addition of 10% HCl-methanol solution (0.5 g), the solvents were removed under reduced pressure, followed by crystallization from ether; upon filtration, the titled compound was obtained as colorless crystals (0.23 g).

後処理

  1. customthe solvents were removed under reduced pressure
  2. customfollowed by crystallization from ether
  3. filtrationupon filtration

出典と根拠

ORDレコード
ord-13d96a448e5a4c50ba187adf97220eb7
出典データセット
uspto-grants-1999_01
特許番号
US05856334

反応ノート

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