5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine → 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine hydrochloride

HRID 341837ノート

反応式

HRID 341837 の反応式
[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([NH2:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22].CO>CO>[ClH:22].[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([NH2:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 158384675,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amineHCID 21893726Hydrochloride methanol

生成物 1

HCID 675980325,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine hydrochloride収率 97.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A portion (1.9 g) of 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-amine obtained in Step 2 of Example 17 was dissolved in methanol (20 mL) and 10% HCl-methanol solution (3.0 g) was added slowly. The solvent was removed under reduced pressure to yield the titled compound as colorless crystals (2.1 g).

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-a5cb1a3c43f941a38c424e054e58c256
出典データセット
uspto-grants-1999_01
特許番号
US05856334

反応ノート

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