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Methyl iodide → 3-Iodo-4,5-dimethoxybenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Benzaldehyde, 4-hydroxy-3-iodo-5-methoxy- | HCID 79499 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Iodo-4,5-dimethoxybenzaldehyde | HCID 2778113 | — |
反応手順
A mixture of 5-iodovanillin (7 g, 25.18 mmole), potassium carbonate (8.78 g, 63.53 mmole) and iodomethane (6.43 g, 45.30 mmole) was suspended in 60 mL of DMF and stirred at room temperature for 14 hours. The reaction mixture was quenched with water and extracted with diethyl ether. The organic layer was dried over MgSO4, filtered and evaporated in vacuo to obtain a solid which was recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05856323 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-cf2a47a2c6ac4469ba02a0f92452f246 |
| 出典メモ | uspto-grants-1999_01 |