Sodium Bicarbonate → Suritozole

HRID 341863ノート

反応式

HRID 341863 の反応式
[CH3:1][N:2]([C:13]([NH:15][CH3:16])=[S:14])[NH:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[CH:6]=1.C(=O)(O)[O-].[Na+]>>[CH3:1][N:2]1[C:13](=[S:14])[N:15]([CH3:16])[C:4]([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[CH:6]=2)=[N:3]1

参加物

3

反応物 2

HCID 516892Sodium BicarbonateHCID 15733509HCID 15733509、化合物

生成物 1

HCID 25431Suritozole

実験手順

2,4-Dimethyl-l-(3-fluorobenzoyl)thiosemicarbazide (11.1 g, 46.0 mmol) and 1 molar aqueous sodium bicarbonate (460 mL, 0.460 mol) were stirred and heated to reflux. After being refluxed for 5 h, the reaction was allowed to cool to room temperature. After stirring overnight, the reaction was placed in the freezer for several hours. The precipitate was then collected by filtration. Crystallization from isopropanol afforded the desired product as colorless, matted needles, mp 126°-128° C.

後処理

  1. temperatureheated to reflux
  2. temperatureAfter being refluxed for 5 h
  3. waitthe reaction was placed in the freezer for several hours
  4. filtrationThe precipitate was then collected by filtration
  5. customCrystallization from isopropanol

出典と根拠

ORDレコード
ord-4a08847f177243c6a5dbe6d3e43abe7d
出典データセット
uspto-grants-1999_01
特許番号
US05856350

反応ノート

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