化工社化工社 化学情報印刷レポート · 研究参考用
1,4-Dibromobutane → 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Dibromobutane | HCID 8056 | — |
| 反応物 | Phenylpropanolamine | HCID 10297 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | beta-Methyl-alpha-phenyl-1-pyrrolidineethanol hydrochloride | HCID 53395958 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol | HCID 4079506 | — |
反応手順
A process for the preparation of [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol hydrochloride or its enantiomer, ##STR12## comprising the steps of (a) refluxing (1R,2S)-(-)-norephedrine or its enantiomer, ##STR13## with 1,4-dibromobutane in the presence of a base, sodium bicarbonate and a solvent, toluene, at a reaction temperature of about 100° to about 120° C. for reaction time of about 12 to about 24 hours, while removing the water formed to give a toluene solution of crude [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05856492 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-6c350b1b5db54b13ad39caa5e131fc1b |
| 出典メモ | uspto-grants-1999_01 |