Benzisothiazole → 3-Chloro-1,2-benzisothiazole

HRID 341975

反応式

HRID 341975 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[N:2]1.S(Cl)([Cl:13])(=O)=O>ClC1C=CC=CC=1>[Cl:13][C:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1][N:2]=1

参加物

4

反応物 2

HCID 9225BenzisothiazoleHCID 24648Sulfuryl chloride

生成物 1

HCID 5981903-Chloro-1,2-benzisothiazole収率 96%

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

実験手順

In a 300 ml four-necked flask equipped with a stirrer, a thermometer, and a condenser, 100 g of monochlorobenzene was placed in advance, to which 27.0 g (0.2 mol) of 1,2-benzisothiazole was added under nitrogen atmosphere. 32.4 g (0.22 mol) Of sulfuryl chloride was added dropwise thereto while stirring at a temperature of from 70° to 80° C. and allowed to react for 1 hour at the same temperature. After the termination of the reaction, the reaction mixture was subjected to distilling off of the solvent and then to distillation under reduced pressure to give 32.5 g of 3-chloro-1,2-benzisothiazole (boiling point: 116° to 118° C./5 mm Hg, melting point: 38° to 40° C.). The yield was 96% to the 1,2-benzisothiazole.

後処理

  1. customIn a 300 ml four-necked flask equipped with a stirrer
  2. additionwas added under nitrogen atmosphere
  3. customto react for 1 hour at the same temperature
  4. customAfter the termination of the reaction
  5. distillationto distilling off of the solvent
  6. distillationto distillation under reduced pressure

出典と根拠

ORDレコード
ord-c4037742b9154d1288c92c8b72230c83
出典データセット
uspto-grants-1999_01
特許番号
US05856504

関連ノート

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