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Malonic Acid → (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)acrylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Malonic Acid | HCID 867 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde | HCID 2795033 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)acrylic acid | HCID 5343159 | — |
反応手順
A mixture of 2,3-dihydrobenzodioxin-5-carboxaldehyde (Morishima, et al., Eur. Pat. Appl. 309,766, 5 Apr. 89) (9.25 g, 56.4 mmol), malonic acid (11.73 g, 112.8 mmol), pyrrolidine (1 mL), and pyridine (25 mL) was heated to reflux for 2 hr, cooled, and then poured into ice water (300 mL). The white precipitate was filtered, washed with 1N HCl, and air dried (9.83 g, 84.6%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05856529 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-3eb3b15e0f8746cdb699671094f732a5 |
| 出典メモ | uspto-grants-1999_01 |