N-Methylallylamine → 4-[3-(4-Bromo-phenyl)-benzo[d]isoxazol-6-yloxy]-but-2-enyl-methyl-amine

HRID 342202

反応式

HRID 342202 の反応式
BrC1C=CC([C:8]2C3C=CC(O)=CC=3O[N:9]=2)=CC=1.BrC/C=C/CBr.Br[CH2:25]/[CH:26]=[CH:27]/[CH2:28][O:29][C:30]1[CH:45]=[CH:44][C:33]2[C:34]([C:37]3[CH:42]=[CH:41][C:40]([Br:43])=[CH:39][CH:38]=3)=[N:35][O:36][C:32]=2[CH:31]=1.C(NC)C=C>>[Br:43][C:40]1[CH:41]=[CH:42][C:37]([C:34]2[C:33]3[CH:44]=[CH:45][C:30]([O:29][CH2:28][CH:27]=[CH:26][CH2:25][NH:9][CH3:8])=[CH:31][C:32]=3[O:36][N:35]=2)=[CH:38][CH:39]=1

参加物

5

反応物 4

HCID 69391N-MethylallylamineHCID 641245trans-1,4-Dibromo-2-buteneHCID 67598022(E)-6-(4-bromo-but-2-enyloxy)-3-(4-bromo-phenyl)-benzo[d]isoxazoleHCID 1354908483-(4-Bromo-phenyl)-benzo[d]isoxazol-6-ol

生成物 1

HCID 867535234-[3-(4-Bromo-phenyl)-benzo[d]isoxazol-6-yloxy]-but-2-enyl-methyl-amine

実験手順

Analogously to Example 1, from 3-(4-bromo-phenyl)-benzo[d]isoxazol-6-ol and (E)-1,4-dibromo-2-butene via (E)-6-(4-bromo-but-2-enyloxy)-3-(4-bromo-phenyl)-benzo[d]isoxazole and by reaction with N-allyl-methyl-amine there is obtained (E)-allyl-[4-[3-(4-bromo-phenyl)-benzo[d]isoxazol-6-yloxy]-but-2-enyl-methyl-amine which is converted into the fumarate, MS: m/e 412 (M30 , 1 Br).

出典と根拠

ORDレコード
ord-1851fae86f134fb38abaccfbc65ba51c
出典データセット
uspto-grants-1999_01
特許番号
US05856503

関連ノート

読み込み中…