Boron tribromide → 3-(4-Bromo-phenyl)benzofuran-6-ol

HRID 342209ノート

反応式

HRID 342209 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([O:17]C)=[CH:16][C:11]=3[O:10][CH:9]=2)=[CH:4][CH:3]=1.B(Br)(Br)Br>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([OH:17])=[CH:16][C:11]=3[O:10][CH:9]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 109027443-(4-Bromo-phenyl)-6-methoxy-benzofuran

生成物 1

HCID 545619733-(4-Bromo-phenyl)benzofuran-6-ol収率 101.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3.0 g of 3-(4-bromo-phenyl)-6-methoxy-benzofuran are treated at 0° C. with 100 ml of 1M boron tribromide solution in methylene chloride. The ice bath is removed and the reaction mixture is stirred, subsequently poured into saturated sodium carbonate solution and extracted with methylene chloride. The organic phases are washed with saturated sodium chloride solution, dried and evaporated. There are obtained 2.9 g of 3-(4-bromo-phenyl)-benzofuran-6-ol, MS: m/e 288 (M+, 1 Br).

後処理

  1. customThe ice bath is removed
  2. additionsubsequently poured into saturated sodium carbonate solution
  3. extractionextracted with methylene chloride
  4. washThe organic phases are washed with saturated sodium chloride solution
  5. customdried
  6. customevaporated

出典と根拠

ORDレコード
ord-eae515a5a6f44a0280d0e37b30718af7
出典データセット
uspto-grants-1999_01
特許番号
US05856503

反応ノート

読み込み中…