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N-Methylallylamine → (E)-allyl-[4-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-yloxy]-but-2-enyl]-methyl-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylallylamine | HCID 69391 | — |
| 反応物 | trans-1,4-Dibromo-2-butene | HCID 641245 | — |
| 反応物 | 1-(4-Bromo-phenyl)-3,4-dihydro-isoquinolin-6-ol | HCID 135980795 | — |
| 生成物 | (E)-allyl-[4-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-yloxy]-but-2-enyl]-methyl-amine | HCID 67597954 | — |
反応手順
Analogously to Example 25, from 1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-ol and (E)-1,4-dibromo-2-butene and after reaction with N-allyl-methyl-amine there is obtained (E)-allyl-[4-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-yloxy]-but-2-enyl]-methyl-amine, which is converted into the fumarate, MS: m/e 425 (M+H+, 1 Br).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05856503 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-92f1078f453840168843e77f32032a66 |
| 出典メモ | uspto-grants-1999_01 |