関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | trans-1,4-Dibromo-2-butene | HCID 641245 | — |
| 反応物 | 4-(4-bromo-phenyl)-1H-benzo[d][1,2]oxazin-7-ol | HCID 135501633 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 7-(4-bromo-but-2-enyloxy)-4-(4-bromo-phenyl)-1H-benzo[d][1,2]oxazine | HCID 67684159 | 78.3% |
反応手順
A mixture of 1.28 g of 4-(4-bromo-phenyl)-1H-benzo[d][1,2]oxazin-7-ol, 2.71 g of (E)-1,4-dibromo-2-butene and 1.74 g of potassium carbonate in 80 ml of acetone is stirred at 65° C. After cooling the reaction mixture is filtered and the filtrate is concentrated and purified by chromatography (silica gel, toluene/acetone 98:2). There are obtained 1.44 g of 7-(4-bromo-but-2-enyloxy)-4-(4-bromo-phenyl)-1H-benzo[d][1,2]oxazine, MS: m/e 437 (64%, M+, 2 Br).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05856503 |
|---|
| 出典データセット | uspto-grants-1999_01 |
|---|
| ORD ID | ord-a8dd78e614b643caa44ffaa4cc4cd5ae |
|---|
| 出典メモ | uspto-grants-1999_01 |
|---|
