8-(4-Propylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 8-(4-Propylphenyl)-1,4-dioxaspiro[4.5]dec-7-ene

HRID 342349ノート

反応式

HRID 342349 の反応式
[CH2:1]1[CH2:20][O:19][C:3]2([CH2:8][CH2:7][C:6](O)([C:9]3[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH3:17])=[CH:11][CH:10]=3)[CH2:5][CH2:4]2)[O:2]1>C1(C)C=CC=CC=1>[CH2:20]1[CH2:1][O:2][C:3]2([CH2:4][CH:5]=[C:6]([C:9]3[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][CH3:17])=[CH:13][CH:14]=3)[CH2:7][CH2:8]2)[O:19]1

参加物

3

反応物 1

HCID 659181288-(4-Propylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

生成物 1

HCID 675902608-(4-Propylphenyl)-1,4-dioxaspiro[4.5]dec-7-ene収率 98.2%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To 500 ml of toluene was dissolved 98 g of the 1,1-ethylenedioxy-4-hydroxy-4-(4-n-propylphenyl)cyclohexane mentioned above, 5 g of Amberlist 15E was added as catalyst thereto, and stirred under a reflux for 2 hours. After the reaction solution was cooled, the catalyst was filtered off. Organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under a reduced pressure to obtain 90 g of 1,1-ethylenedioxy-4-(4-n-propylphenyl)-4-cyclohexene.

後処理

  1. additionwas added as catalyst
  2. temperaturea reflux for 2 hours
  3. temperatureAfter the reaction solution was cooled
  4. filtrationthe catalyst was filtered off
  5. washOrganic layer was washed with water
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationthe solvent was distilled off under a reduced pressure

出典と根拠

ORDレコード
ord-66d19e8404bc48338104789759baed5f
出典データセット
uspto-grants-1999_01
特許番号
US05858275

反応ノート

読み込み中…