Hydrochloric Acid → 5-Cyanopentanoic acid

HRID 342371ノート

反応式

HRID 342371 の反応式
[NH4+].[C:2]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O-:10])=[O:9])#[N:3].Cl>>[C:2]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9])#[N:3]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 19044055HCID 19044055、化合物

生成物 1

HCID 1999265-Cyanopentanoic acid収率 95%

実験手順

A 200-mL portion of the filtrate of the product mixture described above, containing the 5-cyanopentanoic acid ammonium salt (1.13M ), was adjusted to pH 2.5 with 6N HCl, then saturated with sodium chloride and extracted with 4×200 mL of ethyl ether. The combined ether extracts were dried over magnesium sulfate, filtered, and the solvent removed by rotary evaporation at reduced pressure. Remaining ether was removed by stirring the colorless liquid at room temperature under high vacuum (60 millitorr) for 5 h to yield 27.32 g (95% isolated yield) of 5-cyanopentanoic acid. The 5-cyanopentanoic acid was then distilled under vacuum (75 millitorr) at 110°-112° C. without decomposition.

後処理

  1. extractionsaturated with sodium chloride and extracted with 4×200 mL of ethyl ether
  2. dry with materialThe combined ether extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent removed by rotary evaporation at reduced pressure
  5. customRemaining ether was removed

出典と根拠

ORDレコード
ord-a74227d790574eddb5f3f6e397a856cd
出典データセット
uspto-grants-1999_01
特許番号
US05858736

反応ノート

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