Water → 2-(2-Bromophenoxy)cyclohexanone
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C(=O)([O-])[O-].[K+].[K+].Cl[CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C:17]1=[O:22].O>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C:17]1=[O:22]参加物
6
反応条件
- 温度
- 60 °C
実験手順
A mixture of 2-bromophenol (5 g), potassium carbonate (5.99 g) and 2-chlorocyclohexanone (4.22 g) in N,N-dimethylformamide was stirred at 60° C. for 4 hours. The reaction mixture was poured into cold water and the separated oil was extracted with diethyl ether. The extract was washed with water, dried over sodium sulfate and concentrated in vacuo. The residue was crystallized from n-hexane to give 2-(2-bromophenoxy)cyclohexanone (4.36 g).
後処理
- extractionthe separated oil was extracted with diethyl ether
- washThe extract was washed with water
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
- customThe residue was crystallized from n-hexane
出典と根拠
- ORDレコード
- ord-fdcd539dee8f43d48f694902bcd48d5f
- 出典データセット
- uspto-grants-1999_01
- 特許番号
- US05858995
反応ノート
読み込み中…