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N-bromobutanimide → 2-Bromomethyl-7-nitrobenzo[b]furan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 2-Methyl-7-nitrobenzofuran | HCID 13201897 | — |
| 触媒 | 2,2'-Azobis(2,4-dimethyl-4-methoxyvaleronitrile) | HCID 85867 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Bromomethyl-7-nitrobenzo[b]furan | HCID 70201407 | 85.8% |
反応手順
A mixture of 2-methyl-7-nitrobenzo[b]furan (2.66 g), N-bromosuccinimide (3.21 g) and 2,2'-azobis-(2,4-dimethyl-4-methoxyvaleronitrile) (270 mg) in dichloromethane (30 ml) was refluxed for 1 hour. The reaction mixture was washed with aqueous saturated sodium bicarbonate and brine, dried over sodium sulfate and concentrated in vacuo. The residue was crystallized from diethyl ether to give 2-bromomethyl-7-nitrobenzo[b]furan (3.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05858995 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-2f69eb1bd2b8421aa4906d6bbc2b956e |
| 出典メモ | uspto-grants-1999_01 |